Question

The process mass intensity (PMI) allows chemists to calculate how much material is used when generating a target amount of product in a chemical reaction. PMI is expressed as follows: PMI = [(mass of all input materials) / (mass of desired product)] To synthesize moclobemide, an anti-depressant pharmaceutical, 0.00381 moles of 4-(2-aminoethyl)morpholine (C6H14N2O) is dissolved in 20.0 mL of triethylamine (density: 0.726 g mL–1) and 0.00384 moles of 4-chlorobenzoyl chloride (C7H4Cl2O) is added. After rapid stirring for 30 minutes, 10.0 mL (density: 1.00 g mL–1) of water is added followed by 10.0 mL of dichloromethane (density: 1.325 g mL–1) and then the mixture transferred to a separatory funnel. After extraction, the dichloromethane is dried with 5.0 g of magnesium sulfate. At the end of the process, 0.826 g of pure moclobemide is recovered. The PMI for this reaction is:

Answer 1

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