Question

Hello, can someone please answer the followign quesiton.

Which of the following statements about the oxyanion hole in serine proteases are true? 1. This preformed loop is properly positioned to stabilize the negatively charged tetrahedral intermediate involved in amide bond hydrolysis 2. The backbone NH bonds of S195 and G193 create H-bonding interactions with the developing negative charge as S195 attacks the scissile carbon bond 3. It represents an enthalpic interaction that helps stabilize the transition state. 4. It represents an electrostatic interaction that leads to a lower energy state View Available Hint(s) 2, 3, and 4 O1, 2, and 3 3 and 4 All statements are correct.

Answer 1

The true statements about the oxyanion hole in serine protease are as follows: The performed loop is not properly positioned to stabilize the negatively charged tetrahedral intermediate involved in the amide bond hydrolysis. 2) The backbone NH bonds of $195 and G193 create the H-Bonding interactions with the developing negative charged as S195 attacks the scissile carbon bond. The oxyanion hole represents an enthalpic interaction that helps stabilize the transition state. 4) The oxyanion hole represents an electrostatic interaction that leads to a lower energy state. Therefore, the correct statements are 2, 3, and 4.