Question

Questions: 4. Below is a chart of the 5 Gl peptides involved in GI motility. Research the actions of these peptides and list their effects in the chart below. Five GI hormones and their effects: Effect Hormone Gastrin From G cells in the pyloric antrum Cholecystokinin (CCK) From I cells in the duodenum and jejunum Secretin From S cells in the duodenum Glucose Dependent Insulinotropic Peptide (GIP) From cells in the duodenum and proximal jejunum Motilin From cells in the duodenum and jejunum; released about every 90 minutes during the post-absorptive state

Answer 1

Hormone	Effect
Gastrin From G cells in the pyloric antrum	Stimulate release of Gastric juice
Cholecystokinin From I cells in the duodenum and jejunum	Increases digestive enzyme production of pancreas, increase bile production
Secretin From S cells in the duodenum	Regulate PH- increasing bicarbonate secretion and reducing gastric acid secretion.
Glucose Dpendent Insulinotropic Peptide ( GIP ) From cells in the duodenum and proximal jejenum	Stimulate synthesis of Insulin from beta cells of pancreas.
Motilin From cells in the duodenum and jejnum; released about every 90 minutes during the post - absorptive state.	Increase myoelectric complex componenet of GI motility, help in pepsin production ,release of somatostatin

Gastrin

Gastrin is a peptide hormone secreted by G cells in the stomach, duodenum, pancreas. It helps in the secretion of gastric juice ( HCL ) by the parietal cells of the stomach . It also help in vitamin intake and destroy bacteria present in the food.

Cholecystokinin

Cholecystokinin/CCK is a pepetide hormone secreted by I cells in the duodenum and jejenum.It is also known as pancreozymin. It stimulates acinar cells of pancreas to produce pancreatic enzymes, for digestion. It also increases bile production.

Secretin

Secretin is a pepetide hormone of 27 aminoacids produced by S cells in the small intestine. It maintain PH of the duodenum by inhibiting gastric acid secretion and increasing bicarbonate production from pancreas. Also increases bile production.

Glucose Dependent Insulinotropic Pepetide ( GIP )

GIP is a hormone produced by K cells of small intestine. It is included in the family of hormones known as Incretins. It stimulates pancreas to produce insulin from beta cells.

Motilin

Motilin is a peptide secreted by endocrinocytes in the small intestine( secreted by M cells seen in duodenum and jejenum ).It is a protein of 22 aminoacids and have a molecular weight 2698 daltons. Motilin control smooth muscle contractions in the gastrointestinal tract. It also stimulate the production of pepsin. Motilin also increase release of somatostatin. It is known as the housekeeper of the gut.