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Why can micellar electrokinetic chromatography separate neutral molecules? Neutral molecules are...
Why can micellar electrokinetic chromatography separate neutral molecules? Neutral molecules are in a dynamic equilibrium with the micelles which changes the neutral molecules' migration time based on amount of time spent inside the micelle. The micelles induce a negative charge on the neutral molecules depending on their size, which then allows the molecules to migrate towards the cathode. The micelles contribute to the electroosmotic flow, sweeping the neutral molecules towards the detector based on their polarity. The micelles add an element of equilibration time to the van Deemter equation, which helps increase plate height to create a broader range where neutral molecules can be resolved m separations.