Question

What is Enantioselective Carbonyl Reductions Reaction? What products are formed when acetophenone reacts with (S)-CBS and (R)-CBS reagent in presence of water. In the following synthesis steps of salmeterol, a long-acting bronchodilator, what reagent is used and why? What will be the product if treated with (S)-CBS reagent? (R)-Salmeterol is a long-acting bronchodilator used for the treatment of asthma. In this example, the (R)-CBS reagent adds the new H atom from behind, the same result observed with propiophenone. In this case, however, alcohol A has the R configuration using the rules for assigning P

Answer 1

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