(Ph)3P-CH2CH2CH3 CI NaOH iwia 2 eq. H2NCH2CH3 SOCl2, pyridine 1. (CH3CH2CH2)2Culi 2. H20 Conjugate addition Provide...
1. 2. JUST DRAW ARROWS... (CH3)2Culi + CH3Cu Ph CI Ph CH3 The ketone intermediate formed in the reaction of an acid chloride with a Grignard reagent cannot be isolated because it reacts too rapidly with the second equivalent of Grignard reagent. To produce a ketone from an acid chloride, one can treat the acid chloride with a lithium dialkylcopper reagent. The reaction occurs by nucleophilic acyl substitution on the acid chloride by the dialkylcopper anion to yield an acyl...