Positive cooperativity is when binding of a ligand to a protein results in a conformational change...
Positive cooperativity is when binding of a ligand to a protein results in a conformational change that allows increased binding affinity at other ligand binding sites in the same molecule.
Select one:
True
False
Homework Answers
The given statement is True
Positive Cooperativity occurs when the binding of a ligand molecule increases the receptor's apparent affinity, and hence increases the chance of another ligand molecule binding.
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Positive cooperativity is when binding of a ligand to a protein
results in a conformational change...
Ligand binding to a G-protein coupled receptor (GPCR) results in activation of a single G- protein...
Ligand binding to a G-protein coupled receptor (GPCR) results in activation of a single G- protein and then the receptor deactivates. O True False When an activated receptor relays the signal along more than one pathways this is called convergence. O True OFalse Which of the following best describes digestive enzymes? O Hydrolases OLigases Kinases Transferases Decarboxylases Most digestive enzymes are released from cells in an inactive form. True False denatures Protein digestion in humans (and other mammals) begins in...
Assume that the concentration of the ligand is much greater than the concentration of the protein. When ligand Y is pres...
Assume that the concentration of the ligand is much greater than the concentration of the protein. When ligand Y is present at a concentration of 2 x 10-6 M, 50% of the binding sites on the molecules of protein X are found to be occupied. If the concentration of the ligand is increased to 3 x 10-6 M, what fraction of the binding sites will be occupied? Please explain the steps to solve this problem.
Epinephrine is a ligand for the beta-adrenergic receptor. When activated the beta-adrenergic receptor undergoes a conformational...
Epinephrine is a ligand for the beta-adrenergic receptor. When activated the beta-adrenergic receptor undergoes a conformational change that results in the activation of the G protein GsLaTeX: \alpha α . Which of the following secondary messengers would you expect to be increased when epinephrine binds to a beta-adrenergic receptor? DAG cGMP cAMP Ca2+ phospholipase C IP3
Short answer questions: 21. Protein A has a binding site for ligand L with a Ka...
Short answer questions: 21. Protein A has a binding site for ligand L with a Ka of 10-6 M. Protein B has a binding site for ligand L with a Ka of 10'M. (a). Which protein has a higher affinity for ligand L? Explain your reasoning. (b). At what concentration of ligand L is proteins A half-saturated. At what concentration of L is protein B half-saturated. [L] y = [L] + Ka 22. A protein binds to a ligand L...
1. Protein kinases phosphorylate target enzymes and as a result enzymes become activated or inactivated. Which...
1. Protein kinases phosphorylate target enzymes and as a result enzymes become activated or inactivated. Which of the statements are TRUE? (Multiple answers: You can select more than one option) A. Phosphorylated enzymes behave like competitive inhibitors B The presence of a phosphate acts as a non-competitive inhibitor/activator. No change in Km but significant change in Vmax C. The presence of a phosphate group induces a conformational change that modifies the affinity and catalytic ability of a target enzyme D....
The binding of which host receptor induces the conformational change of the HIV fusion protein? OCD4...
The binding of which host receptor induces the conformational change of the HIV fusion protein? OCD4 Sialic acid Heparin sulfate CCR5 The subviral structure that forms after HIV enters into cells serves multiple purposes including which of the following? (Check all that apply) O prevents ribosomes from accessing the ss (+) RNA genome Allows for production of mRNA Forms the structural basis for new viral particles O Allows entry of dNTPs so the reverse transcriptase enzyme can generate dsDNA
A binding protein binds to a ligand with Kd=30nm. What is the concentration of ligand when...
A binding protein binds to a ligand with Kd=30nm. What is the
concentration of ligand when the [L] when the fraction
bound,,
is a) 0.25, b) 0.6 and c) 0.95.
Dimoglobin as a case study in cooperativity. Note that each binding site can be occupied, ,...
Dimoglobin as a case study in cooperativity.
Note that each binding site can be occupied,
, or unoccupied,
, and that a parameter J describes the cooperativity between the O2
molecules when both states are occupied (i.e., the energy is not
just the sum of the individual binding energies).
a) Write down the weights (Gibbs factors) for each of the
different states for the dimoglobin system shown in Figure 2.
b) What is the formula that describes the energy of...
A. You are performing experiments with your protein of interest and its ligand. You are attempting...
A. You are performing experiments with your protein of interest and its ligand. You are attempting to mutate the binding site of your protein to disrupt binding to ligand to see what happens inside the cell. You make a series of mutations and one in particular gives you surprising results: you observe that the mutation that you made in an amino acid that sticks out into the binding pocket actually increases the protein’s affinity for the ligand. Give a molecular...
Ligand binding to a G-protein coupled receptor (GPCR) results in activation of a single G- protein and then the receptor deactivates. O True False When an activated receptor relays the signal along more than one pathways this is called convergence. O True OFalse Which of the following best describes digestive enzymes? O Hydrolases OLigases Kinases Transferases Decarboxylases Most digestive enzymes are released from cells in an inactive form. True False denatures Protein digestion in humans (and other mammals) begins in...
Short answer questions: 21. Protein A has a binding site for ligand L with a Ka of 10-6 M. Protein B has a binding site for ligand L with a Ka of 10'M. (a). Which protein has a higher affinity for ligand L? Explain your reasoning. (b). At what concentration of ligand L is proteins A half-saturated. At what concentration of L is protein B half-saturated. [L] y = [L] + Ka 22. A protein binds to a ligand L...
The binding of which host receptor induces the conformational change of the HIV fusion protein? OCD4 Sialic acid Heparin sulfate CCR5 The subviral structure that forms after HIV enters into cells serves multiple purposes including which of the following? (Check all that apply) O prevents ribosomes from accessing the ss (+) RNA genome Allows for production of mRNA Forms the structural basis for new viral particles O Allows entry of dNTPs so the reverse transcriptase enzyme can generate dsDNA
A binding protein binds to a ligand with Kd=30nm. What is the
concentration of ligand when the [L] when the fraction
bound,,
is a) 0.25, b) 0.6 and c) 0.95.
Dimoglobin as a case study in cooperativity.
Note that each binding site can be occupied,
, or unoccupied,
, and that a parameter J describes the cooperativity between the O2
molecules when both states are occupied (i.e., the energy is not
just the sum of the individual binding energies).
a) Write down the weights (Gibbs factors) for each of the
different states for the dimoglobin system shown in Figure 2.
b) What is the formula that describes the energy of...
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