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Chemistry 425 Problem Set Unit 1 1. Circle the species that would be predominant free in water at physiological pH. Y er ve

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H* Hас CHз CHз pKa -6.2 The protonated ketone carbonyl is more acidic as the pKa is very low. Thus at physiological pH it wilpKa is more than the physiological pH hence the protonated form is favored. OH pKa 10 = 0 0 pKa is more than the physiologicaammonium ion pKa =~10.6 H pKa is lower than the protonated GUANIDINIUM moiety N NH wwww.amwwmum ammonium ion pKa = ~40 pKa is

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