Question

If an antigen mutates, will the same lymphocytes recognize it? Why or why not? 5. HIV (the virus that causes AIDS) specifically targets the helper T-lymphocytes, causing the destruction of these cells. Given the role of helper T-lymphocytes, why does this disease increase a person’s susceptibility to infectious diseases?

Answer 1

Anower : If an antigen mutates, will the same lymphocytes recognize it ? Why or Why not? T and B cells whose receptors bind belf antigens with strong affinity Cross reactivity means each unique T cell CTCR) or B cell CBCR) receptor has the capacity to bind a range of related antigens, i.e, it will bind some of them with very high affinity, others with much lower, but bind them all it will This is the adaptive immune system's way of hedging its bets to ensure that circulating T and B cells can more or less bind whateves antigen comes their way. In other words, TCRs and B CRs are promiscuous, - capable of binding more than one antigen. 0 Why does HIV disease increase a person's susceptibile to Infectious disease ? > HIV: Human Iwmmunodeficiency wis es causes AIDs:- Acquired Immunodeficiency Syndrome - In this disease the immune system of whole body is damaged HIV Interferes with bady's ability to fight

against any Infectious disease HIV destroys CD4 T cells - White blood cells that play a large role in helping aus body fight disease The fewer CD4 T cells you have, the weaked your immune system becomes