Question

Indolmycin is an antibiotic isolated from an African strain of streptomyces Albus. It exhibits antimicrobial activity against strains of staphylococci resistant to commercial antibiotics. Circle and assign R or S designation to any three chiral atoms Dipole measurements suggest that m 1, 2-dimethoxyethane the anti-staggered conformation is the more staple However, in 1.2-ethanediol the gauche staggered conformation is the more stable 1.2-ethanediol HOCH_2CH_2OH CH_3OCH_2CH_2OCH_3 1.2 -dimethoxyethane Draw the Newman projection along the C-C bond for both the anti-staggered and the gauche-staggered conformations of 1.2-dimethoxy ethane Do the same tor 1, 2-ethanediol Explain why in 1, 2-ethanediol the gauche-staggered conformation is the more stable include drawings to illustrate your logic Explain why m 1, 2-dimethoxyethane the anti-staggered conformation is the more stable Include drawings to illustrate your logic

Answer 1

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oCHs 3 Gauche Stagerred 1,2-dimethoxyethane OCH3 Anti Staggered CH3 OH OH Gauche Staggered This structure is stabilizec hydrogen bonding OH Anti он 1,2-ethanediol