Question

5. Calculate the pH at which thioridazine hydrochloride (pk, -9.5, M, 407 g mot') wi 0.407% w/v solution. The solubility of the unionised species is 1.5 x 1o-M. [5.68] 6. In reference to question 5 above, how could we increase the solubility of thioridazine in solution at pH 5.7 without altering the pH of the solution? ill precipitate from as1s0

Please regard as one question. Thanks

Answer 1

uaton① S-So Bastc ane more soluble n audic Solubon we use, equabon ① to alculate the PH above ohch thiondagne votll pred S-So ahwaton dolubrty at the fount Sp = 1.5 x 106 mol dm? concentration e colubon o. 404 X hh, moles Guam molecula.seyh上 o (n) 3 lx to moldm
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NOりー@sx1ざ) H-9. S-3.284 tahes plate Solub必 on -the -ク pH and oncentration

-thtoidagtne on the PH and oncen-tration Solubilby an be achieved toniuabon and mean sige recduchon