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Testbank, Question 100 Which of the following reagents is used to protect the amino group in the selective synthesis of the d
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Answer #1

In dipeptide synthesis, amines are commonly protected by – FMOC ( fluorenylmethyloxycarbonyl) , Cbz ( carboxybenzyl) BOC (tertiary butyl oxy carbonyl) groups.

The FMOC group is added using the compound FMOC-Cl, Cbz is added using Cbz-Cl and BOC is added using BOC anhydride ( BOC)2O. These reagents are all accompanied with a base ( eg: Et3N)

Their structures are :


CI FMOC-C1 Cbz-C1 (BOC)20

So, compound II is the answer.

The rest of them don't react / are not easily removed during deprotection.

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