6-8 6. Which of the following alkyl-substituted aromatic compounds will be the least ortho directing? a....
Question 3
1s 3 ORTHO Today we learned about adding a second group to a mono-substituted benzene ring. Any group on a benzene will affect the rate of the reaction (activated or deactivated relative to benzene) and the regioselectivity Where does the electrophile add? Ortho? Meta? Para? Some combination thereof? We found that EDGs (electron-donating groups) direct the electrophile to the ortho and para positions while EWGs (electron-withdrawing groups) direct the electrophile to the meta position. Now, it is time...
5. All electron-donating groups are activating groups and all are ortho-para directors with the exception of substituents, all electron-withdrawing groups are deactivating groups and all are meta directors. A. hydroxyl B. amino C. halogens D. alkoxyl 6. Hydrogen abstraction from the methyl group of methylbenzene (toluene) produces a radical called the radical. A. allylic B. free C. halogen D. benzyllic 7. The stability of benzyllic radicals can be explained by theory. A. resonance B. bond order C. inductive D. molecular...
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Challenge Problem 08.94 9-Borabicyclo[3.3.1]nonane (9-BBN) is a reagent commonly used in the hydroboration of alkynes, but it can also be employed in reactions with alkenes. The following table provides the relative rates of hydroboration (using 9-BBN) for a variety of alkenes (J. Am. Chem. Soc. 1989, 111, 1414-1418) : Relative Reactivity Alkenes CH—CHОBU, 1 CH2 CHBu, 2 CH2-CHCH2OMe, 3 CH CHOAC, 4 CH2 CHCH2OAC, 5 сH—CHCH,CN, 6 CH2 CHCH2C, 7 cis-2-Butene, 8 tans-CH,CH,CHСHC,...
1. please check what is wrong. Thank you!
Determine the product formed when each compound is treated with Br2 and FeBr3. Drag the atom labels to their appropriate positions. CN Atom labels H H Br Br2 A. FeBr Br H OH OH Br Br. Br2 FeBr3 H H Br Br H Br2 FeBr H1 H Reset T Rank the compounds in each group in order of decreasing reactivity in electrophilic aromatic substitution. CI Decreasing reactivity Rank the compounds in each...
Question1:
Introduction Three aromatic compounds that have ortho-para directing and activating substituents will be brominated. The extent of activation will be judged by the number of bromine atoms that add to the benzene ring in each case. For each of the compounds shown below you will work out if a mono- di- or tri- brominated derivative formed following treatment with acetic acid and bromine in hydrobromic acid. This will be determined by measuring the melting point and interpreting the H...
8. In the section "Designing the Drug Thalidomide", you
learned that researchers create various analogues to determine
which structural features are necessary for biological activity and
which are responsible for side effects. The analogues were created
using the molecule shown below. Using the information found in
Tabkw 3, sraw the corresponding analogs #7, 8, and 11.
9. Thalidomide is known to be an inhibitor of TBF-a. TNF-a is
a protein mediator, and when to much of this mediator is present,...