Question
product the product for the following reaction carboxylic acid + h2so4 heat

B. NBS NaoMe МОН 0°C tBuCOtBu CO E A. NBS - N-bromosuccinimide Ph OTBS 90°C CO,CH C. 1. MgBr (CHOTMS 1. DIBAL-H 2. H0 2. H,0
0 0
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Answer #1

A) intramoleculer aldol reaction

B)NBS in presence of peroxide gives alylic bromination

C) 4+2 thermal cycloaddition reaction

D) DIBAL-H reduce -CN to CHO in presence of acid . Since OTs group is sensitive to acids ,it is deprotected to alcohol in presence of acid H3O+

vo Naone A) intramoleculer aldol rxh enolate EICB Product ren B2 NBS T tBuoootBu 1 allglic position SE alleglic bromination B

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