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Question Cl OH CH3 pKa 3 pKa 8 pKa 8 Cetirizine (Zyrtec) Clemastine (Tavist) 1) Identify the functional groups present in Zyrtec and Tavist 2) Draw the structure of the drug at pH 1 and at pH 7 3) TUMS neutralizes stomach acid to pH 3.5, draw the structure of the drug at pH 3.5 Will the patient get the full antihistaminergic effect if he takes TUMS with the agents above? Among other processes antihistaminergic effect involves absorption of the drug and transport to its site of action. 4) 42
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C14 fJ CH3 Cl in these dut Etheん 0 acid TN avomalic hydve cantonTha OM cOMDon オ anbon amina aue オCarboxylic acil Vi

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