Question

The local anesthetic, benzocaine, can be prepared by the direct esterification of p-aminobenzoic acid with ethanol, using sulb Benzocaine precipitates during the neutralization procedure. Explain. and the Before neutralization the solution When the sb: Before neutralization the solution (is acidic/is basic) and the (protonated amino group/deprotonated amino group/protonated ester group) makes benzocaine soluble in the aqueous solution. When the sodium carbonate is added, the (amino group is deprotonated/amino group is protonated/ester group is deprotonated) and the neutral benzocaine produced has a (low solubility in water/high solubility in water/higher density than water).

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Answer #1

a) On Addition of Sodium Carbonate,

  • CO​​​​​2Gas is produced.

b) Before Neutralisation, the Solution is Acidic and the Protonated Amino Group makes Benzocaine soluble in the Aqueous Solution. When the Sodium Carbonate is added, the Amino Group is deprotonated and the Neutral Benzocaine produced has a Low Solubility in Water.

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