6. The following synthesis can be used to produce DEET, a mosquito repellant. Determine the structure...
1) Br 2) 3) 4) 5) DEET (the active ingredient in over the counter insect repellant) SOCl2 CO2 HN(CH2CH3)2 (1 equiv.) NaCN Br2, FeBr3 CH3CH2OH H3O* NaNH2 H2CO CH3CH2Br CH3CH2NH2 HCooCH3 CH3COOHMg, ether NH(CH2CH3)2. (2 equiv.)
The structure of DEET, used as an insect repellent, is shown below. Please answer the following questions based upon the structure. (a) What is the shape of the atom labeled 1 ? lineartrigonal planarbent at =120°tetrahedraltrigonal pyramidalbent at =109°(b) What is the bond angle of the atom labeled 3?10912018090(c) What is the hybridization of the atom labeled 3?(d) Which atoms have three dimensional structure? (Select all that apply.)123456
Draw the structure Unsymmetrical ethers can be made by the Williamson synthesis, in which an alkoxide ion reacts with an alkyl bromide. Draw the structure of the alkoxide and the alkyl bromide needed to produce 2-ethoxy-2-methylpropane (a.k.a t-butyl ethyl ether), shown below. Show charges where appropriate. alkoxide alkyl bromide ether Br
1) What are the products of the following sequence of reactions? Write the structure of the intermediates (reaction with Mg), and the structure of the final product. 1) Mg, Diethyl ether Н.о А В Br A) 2-butanol and MgHBr C) butane and Mg(OH)Br B) butane and MgHBr D) 2-butanol and Mg(OH)Br 2) What is the major product of the following reaction? Write the structures of intermediates and the products. 2) G) PO 2. H,о* Mg, Diethyl ether А 1. Н,С-0...
4. Synthesis Reactions. Draw the feature product of the following reactions. (8 x 3 pts) 1. Mg Ph Br 2. CO2 3. H a "NH2 Ph 1. NaOH, CI 2. LAIH b. CHỊCH NHA NaBHgCN, H+ Ph C. Br (excess) NH d NaOH H HO OH H CH e. 1. NaOH H2O NH 2. H+ o= 1. NaOH H2O 2. SOCI N(CH3)2 3 HO
5. Draw the intermediates and final product for the following synthesis (Full: all products correct with no more than 1 minor error, partial: 3 out of 4 correct with no more than 1 minor error) Mg, Et,0 Br 1, CO, 2. H, H20 SOCI NH2
Unsymmetrical ethers can be made by the Williamson synthesis, in which an alkoxide ion reacts with an alkyl bromide. Draw the structure of the alkoxide and the alkyl bromide needed to produce 2-ethoxy-2-methylpropane (a.k.a t-butyl ethyl ether), shown below. Show charges where appropriate. alkoxide alkyl bromide ether + Br
4. Synthesis Reactions. Draw the feature product of the following reactions. (8 x 3 pts) 1. Mg Ph Br 2. CO2 3. H+ 1. NaOH, ANH, 1. NaOH, CANADA ? 2. Lialla NH2 2. LiAIH4 CH3CH2NH2, NaBH3CN, H+ c. PhD Br (excess) CNH LB (excess) NaOH H+ YO- OH . H' CH3 1. NaOH, H2O NH - 2. H+ 1. NaOH, H2O 2. SOCI . N(CH3)2 HO فه H2NCH3 OCH3
8. Is the following sequence of steps an appropriate synthesis for ibuprofen? Yes or No CHCH CH,CH3 HOCH CH OH (CH)2CHCc на AIClh CH CH3 Br -CHCH HOOC-CHCH3 HOOC-CHCH3 1.Mg, ether NES H2/Pd 3. Ho* 8. Is the following sequence of steps an appropriate synthesis for ibuprofen? Yes or No CHCH CH,CH3 HOCH CH OH (CH)2CHCc на AIClh CH CH3 Br -CHCH HOOC-CHCH3 HOOC-CHCH3 1.Mg, ether NES H2/Pd 3. Ho*
Practice Problem 11.15a Identify reagents that can be used for the following synthesis: Draw the structure of compound A. Practice Problem 11.15a Identify reagents that can be used for the following synthesis: он Compound A он correct. Identify reagent(s) that can be used to convert the starting alcohol into compound A. (1) TsCI, py; (2) NaOMe H2, Pt H2504 (1) TSCl, py; (2) t-BuOk SHOW ANSWER X Incorrect. Draw the structure of compound A 2 Edit Correct Identify reagent(s) that...