Question

Which of the following compounds are potentia acetic ester synthesis? ne rollowing compounds are "potential' targets for either the malonic ester or the aceto hem. For each of these, draw the structurels) of the alkylating agents and indicate if the compound could be made efficiently by this method.

Answer 1

1) My, ether Carbonation of -CooH Grignand 2) CO₂, 3) HO со он KMnou Z oxidation of hydro carbon Kinou Lot oxida oxidative cleavage cyclohexane of derivative -OH OH D Pera ROH 2) Nach Hydrolysis of nitrile made from 5-l alcohol we

Malonic ester by acetoacetic coort 1) Naget glooc. coort -COOEX 1) Nao y 2) enrer clooc coort ) Naoh 2) t₂ otla en Pr OH MY H cooet Good method is Na Oct a oct atooc, coort 1) Naoet b) •cooet D. No good coort 1) NGOH n coort COOH coort - 2) , Br 2) H₃0t/ c) at NOT Good merhod vinyl bromide very unreachine, į la 1 Na oet o or Naort o st in NaOH 2) v Brn 2) Hola ! l (Good) allyl bromide easily reacts d) 1 Noort i thout 1 Naot 1) NaOH 2) y Br 2) - Br 25 H₂5/A tout " (undergoes elmination) ? rather than SNI (NOT Good method]