Question

What is the equilibrium ratio of the molecule to the left compared to the molecule on the right at 25°C? CH3 H3C 7.5 kJ/mol hCan I get an explanation on how this works?

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CH3 TH Axial Equatorial 85:15 By being on the equatorial positions, bulkier groups are allowed to remain as away as possibleclz H re 1,3-diaxial Interactions Substituents on the chair conformation prefer to be in the equatorial position. The reason

Thus axial substitution is highly unstable due to 1,3 interactions and is disfavoured ; at equilibrium both substitution exist but axial exists in a very trace amount.

The ratio of equatorial : axial is nearly 85 :15

But some scientific papers support that the ratio can be as high as 95:5

Option C is most accurate answer

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