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(2) Review of Substituent Effects: (a) For each benzylic carbocation below: (1) indicate if the substituents...
(1) indicate if the ring substituent is Electron Donating (EDG), Electron Withdrawing (EWG) or Neither (N):...
(1) indicate if the ring substituent is Electron Donating (EDG), Electron Withdrawing (EWG) or Neither (N): (11) rank them in order of their reactivity towards EAS (1 = fast........4 = slow) en T-Br -NO, NO2 TOCH; -OCH;
2 pts) is the skene in question 1 conated? Yes conjugated not conjugated 3. (6 pts) Rank the stability of the follow...
2 pts) is the skene in question 1 conated? Yes conjugated not conjugated 3. (6 pts) Rank the stability of the following carbocations in the boxes (1=most stable to 3=least stable). Below each carbocation, select all the types of stabilization that carbocation experiences. OH O -EWG O -EDG O' -EWG Hyperconjugation OA-EWG O -EDG -EWG Hyperconjugation O EWG O -EDG O -EWG Hyperconjugation
1 - Discuss correctly why each substituent favors the observed major product. (e.g. stability of the...
1 - Discuss correctly why each substituent favors the
observed major product. (e.g. stability of the carbocation
intermediate resonance hybrid, steric hindrance at reaction
location) How does the stability of the intermediates (from the
handout done during the lab) rationalize the observed products
formed? Do more stable intermediate lead to more products or
less
2- Create a general rule that correctly correlates
EDG/EWG behavior of a substituent and the preferred regiochemistry
of the reaction. Where do EDGs tend to substitute?...
1. please check what is wrong. Thank you! Determine the product formed when each compound is treated with...
1. please check what is wrong. Thank you!
Determine the product formed when each compound is treated with Br2 and FeBr3. Drag the atom labels to their appropriate positions. CN Atom labels H H Br Br2 A. FeBr Br H OH OH Br Br. Br2 FeBr3 H H Br Br H Br2 FeBr H1 H Reset T Rank the compounds in each group in order of decreasing reactivity in electrophilic aromatic substitution. CI Decreasing reactivity Rank the compounds in each...
0.67/1 pts Partial Question 10 For each series of three compounds choose the one that is...
0.67/1 pts Partial Question 10 For each series of three compounds choose the one that is the most reactive for the reaction in the box. In the feedback, EDG-Electron Donating Group and EWG - Electron Withdrawing Group. The most reactive compound in Series #1 is: B (Chapter 11) The most reactive compound in Series #2 is: E (Chapter 13) The most reactive compound in Series #3 is: H-A (Chapter 10) the active pre NO CHORYCH Answer 1: B Choose the...
1. For the following compounds, label each substituent as electron donating or electron withdrawing, and indicate...
1. For the following compounds, label each substituent as electron donating or electron withdrawing, and indicate whether this effect is achieved via induction or resonance. ŅO2 H2N SO3H 2. Predict the TH NMR of the above benzene derivatives. For chemical shift, indicate whether the peak would likely be downfield or upfield of benzene (7.2 ppm). (Hint: think about the resonance structures that can be drawn based on your responses from above) A B # of peaks chemical shift indicate: >7.2,...
9. (a)Rank each of the carbocations below in the order of indu -1) and explain the...
9. (a)Rank each of the carbocations below in the order of indu -1) and explain the logic underlying your ranking. (4 points) Her of increasing stability (most stab 10 (b) Show all rearrangements that could occur that wou carbocation in each of the following: (10 points) ould occur that would result in a more stable o den) svo vo l ed i vores
8. In the section "Designing the Drug Thalidomide", you learned that researchers create various analogues to...
8. In the section "Designing the Drug Thalidomide", you
learned that researchers create various analogues to determine
which structural features are necessary for biological activity and
which are responsible for side effects. The analogues were created
using the molecule shown below. Using the information found in
Tabkw 3, sraw the corresponding analogs #7, 8, and 11.
9. Thalidomide is known to be an inhibitor of TBF-a. TNF-a is
a protein mediator, and when to much of this mediator is present,...
3. Draw a stepwise, detailed mechanism for the acid-catalyzed hydration reaction in question 2 above. Use...
3. Draw a stepwise, detailed mechanism for the acid-catalyzed hydration reaction in question 2 above. Use curved arrows to indicate the flow of electrons. (Note: use hydronium ion, H307, in your mechanism to indicate "acidic water"). (6 pts) 4. Draw a stepwise, detailed mechanism for the reaction below. Use curved arrows to indicate the flow of electrons. (Hint: think of this reaction as a combination of addition of HX (step 1) and hydration (step 2)]. In the second step, an...
3. Indicate the type e the type of fundamental mechanistic step displayed in each of the...
3. Indicate the type e the type of fundamental mechanistic step displayed in each of the following transformations. Use on transfer. NA for nucleille attack LG for loss of leaving group, and R for rearrangement NA 4. Rank the following carbocations in order of stability (1 MOST-3 - LEAST). For the second set, one of the three is more stable the others due to resonance Circle the one that exhibit this property Dowarows showing the mechanism nowotections of the following...
(1) indicate if the ring substituent is Electron Donating (EDG), Electron Withdrawing (EWG) or Neither (N): (11) rank them in order of their reactivity towards EAS (1 = fast........4 = slow) en T-Br -NO, NO2 TOCH; -OCH;
2 pts) is the skene in question 1 conated? Yes conjugated not conjugated 3. (6 pts) Rank the stability of the following carbocations in the boxes (1=most stable to 3=least stable). Below each carbocation, select all the types of stabilization that carbocation experiences. OH O -EWG O -EDG O' -EWG Hyperconjugation OA-EWG O -EDG -EWG Hyperconjugation O EWG O -EDG O -EWG Hyperconjugation
1 - Discuss correctly why each substituent favors the
observed major product. (e.g. stability of the carbocation
intermediate resonance hybrid, steric hindrance at reaction
location) How does the stability of the intermediates (from the
handout done during the lab) rationalize the observed products
formed? Do more stable intermediate lead to more products or
less
2- Create a general rule that correctly correlates
EDG/EWG behavior of a substituent and the preferred regiochemistry
of the reaction. Where do EDGs tend to substitute?...
1. please check what is wrong. Thank you!
Determine the product formed when each compound is treated with Br2 and FeBr3. Drag the atom labels to their appropriate positions. CN Atom labels H H Br Br2 A. FeBr Br H OH OH Br Br. Br2 FeBr3 H H Br Br H Br2 FeBr H1 H Reset T Rank the compounds in each group in order of decreasing reactivity in electrophilic aromatic substitution. CI Decreasing reactivity Rank the compounds in each...
0.67/1 pts Partial Question 10 For each series of three compounds choose the one that is the most reactive for the reaction in the box. In the feedback, EDG-Electron Donating Group and EWG - Electron Withdrawing Group. The most reactive compound in Series #1 is: B (Chapter 11) The most reactive compound in Series #2 is: E (Chapter 13) The most reactive compound in Series #3 is: H-A (Chapter 10) the active pre NO CHORYCH Answer 1: B Choose the...
1. For the following compounds, label each substituent as electron donating or electron withdrawing, and indicate whether this effect is achieved via induction or resonance. ŅO2 H2N SO3H 2. Predict the TH NMR of the above benzene derivatives. For chemical shift, indicate whether the peak would likely be downfield or upfield of benzene (7.2 ppm). (Hint: think about the resonance structures that can be drawn based on your responses from above) A B # of peaks chemical shift indicate: >7.2,...
9. (a)Rank each of the carbocations below in the order of indu -1) and explain the logic underlying your ranking. (4 points) Her of increasing stability (most stab 10 (b) Show all rearrangements that could occur that wou carbocation in each of the following: (10 points) ould occur that would result in a more stable o den) svo vo l ed i vores
8. In the section "Designing the Drug Thalidomide", you
learned that researchers create various analogues to determine
which structural features are necessary for biological activity and
which are responsible for side effects. The analogues were created
using the molecule shown below. Using the information found in
Tabkw 3, sraw the corresponding analogs #7, 8, and 11.
9. Thalidomide is known to be an inhibitor of TBF-a. TNF-a is
a protein mediator, and when to much of this mediator is present,...
3. Draw a stepwise, detailed mechanism for the acid-catalyzed hydration reaction in question 2 above. Use curved arrows to indicate the flow of electrons. (Note: use hydronium ion, H307, in your mechanism to indicate "acidic water"). (6 pts) 4. Draw a stepwise, detailed mechanism for the reaction below. Use curved arrows to indicate the flow of electrons. (Hint: think of this reaction as a combination of addition of HX (step 1) and hydration (step 2)]. In the second step, an...
3. Indicate the type e the type of fundamental mechanistic step displayed in each of the following transformations. Use on transfer. NA for nucleille attack LG for loss of leaving group, and R for rearrangement NA 4. Rank the following carbocations in order of stability (1 MOST-3 - LEAST). For the second set, one of the three is more stable the others due to resonance Circle the one that exhibit this property Dowarows showing the mechanism nowotections of the following...
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