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Which subtrate produces NADH the fastest between Ethanol, Methanol, Isopropanol and Acetone? What does this imply...

Which subtrate produces NADH the fastest between Ethanol, Methanol, Isopropanol and Acetone?

What does this imply about how well each substrate binds to the enzyme ADH?

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Answer #1

Methanol produces the NADH fastest between ethanol, methanol, isopropanol and acetone.

This imply about how well these substrates bind to the enzyme alcohol dehydrogenase is that methanol is simplest primary alcohol and does not have any steric interference effect. So it fit very well in the active site of enzyme and produces NADH without any steric interference/ steric hindrance, whereas isopropanol is secondary alcohol which exhibit steric interference at the active site of enzyme more than methanol whereas acetone is a ketone and for tis oxidation C-C bond is to be broken which is resisted in normal condition and it has also has more steric interference than methanol. Ethanol also has more steric hindrance effect than methanol on the active site of enzyme. So, methanol produces the NADH fastest between ethanol, methanol, isopropanol and acetone. .

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