Question

Case Study Questions I. Cocaine (in the form of cocaine hydrochloride) but not by smoking. However, the free this? une form of cocaine hydrochloride) is usually consumed by drinking, snorting, or injecting, by smoking. However, the free base form of cocaine is smoked. What is the likely reason for 2. The late comedian Richard Pryor performed a skit poking fun at himself for an caused an explosion and ignited himself attempting to smoke "freebase." Do you think that such an incident is possible? Before responding, consider the steps that would be required to separate out the free base from an aqueous reaction mixture. Explain the reason for your answer. Crack cocaine presumably got its name from the "cracking" sound it makes when being smoked. Why do you think it makes this sound? 4. What chemical reaction(s) would occur if NaOH were used instead of baking soda to make crack cocaine? Write a mechanism for the reaction(s) proposed. (Start with Figure 2) 5. Complete the reaction scheme proposed by Professor Martinez for the synthesis of cocaine by adding the necessary reagents/reaction conditions. Write mechanisms for each of the reaction steps that you added the reagents to. (use Fiqure 3) A researcher is involved in pharmacological studies of cocaethylene and would like to synthesize it from cocaine. She seeks your advice on a suitable synthetic route. Outline a synthetic scheme that you would suggest to her. Post-Case Questions ate and read the article that Professor Martinez referred to. Respond to Ling's question in less than 250 words. he larger implication of the referenced study (beyond that of a lead for a possible cure for cocaine addiction)?

answer question 6 with simple explanation and simple mechanism

Answer 1

Answer:- Metabolic production from cocaine :- Cocaethylene is a byproduct of concuvent consumption of cocaine and alcohol as metabolised by the liver. Metabolism gegn of cocaine produces two biologically inactive metabolites mamely benzoyle cgonine and ecgonine methyl ester in the paiesence of engyene carboxylesterase. [Reaction involved :) Cocaine + H2O -> benzoylecgonine + methancel Benzoylecgonine + ethanol = cocaethylene + H2O Cocaine + ethanol - cocaethylene + methanol