Question

Check which of the following statements are TRUE.

	A.	Ketones are more reactive as electrophiles than aldehydes.
	B.	One method of shifting the equilibrium in the direction of the ester, in the Fischer esterification reaction, is to remove water as it is formed.
	C.	Methoxy benzene is an activator AND a meta-director
	D.	The following sequence will result in formation of a ketone 1. RCOCl, Ph2CuLi 2. H3O+
	E.	When a ketone is reacted with LDA (iPr2NLi), the LDA is more likely to act as a base rather than a nucleophile.

Answer 1

True statemets.

B.One method of shifting the equilibrium in the direction of the ester, in the Fischer esterification reaction, is to remove water as it is formed.

Explanation-In Fisher esterification, the equilibrium is shifted towards products by using a large excess of the alcohol and also removing water as it it formed.

D. The following sequence will result in formation of a ketone

1. RCOCl, Ph2CuLi 2. H3O+

E.When a ketone is reacted with LDA (iPr2NLi), the LDA is more likely to act as a base rather than a nucleophile.

Explanation-The steric bulk of its isopropyl groups makes LDA non- nucleophilic. Even so, it's a strong base rather than nucleophile.