Question

The molecule 1, is well known mechanism based inhibitor for one of the PLP containing enzyme. The molecule can adopt either pathway A or B, and can lead to I or II adduct formation. One adduct was formed from 1 covalently linked to pyridoxal 5-phosphate (PLP) (I) while the other adduct was formed with the inhibitor covalently linked to Lysine246, the active site lysine. NH 0 o,po HN н. Lys HN Co.
media%2Fc15%2Fc15a6f13-adde-47f5-ba32-dd
0 0
Add a comment Improve this question Transcribed image text
Answer #1

Answer:

1)

NH HN E-S OOC 1-12N NH 1H E-P HaN

Add a comment
Know the answer?
Add Answer to:
The molecule 1, is well known mechanism based inhibitor for one of the PLP containing enzyme....
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Not the answer you're looking for? Ask your own homework help question. Our experts will answer your question WITHIN MINUTES for Free.
Similar Homework Help Questions
  • 3. It is uncommon for one molecule to act as both an activator and inhibitor in...

    3. It is uncommon for one molecule to act as both an activator and inhibitor in metabolism. Which of the following molecules both activates glycolysis and inhibits gluconeogenesis? A. NAD B. Fructose 1,6-bisphosphate C. Pyruvate D. Fructose 2,6-bisphosphate E. Glucose 6-phosphate 4. Regulation of phosphorylase is by phosphorylation. However, this covalent modification increases or decreases activity without completely inhibiting it. The velocity plot is sigmoidal. What statement can be made about this enzyme? A. It likely follows a Michaelis-Menten kinetic....

  • Biochemistry. Please answer all completely. 13. Identify the electrophilic center and nucleophile in the below image...

    Biochemistry. Please answer all completely. 13. Identify the electrophilic center and nucleophile in the below image : R 14. Give an example of amino acids with R group shown below which can function as nucleophile during enzyme catalysis. Nucleophiles Negatively charged oxygen (as in an unprotonated hydroxyl group or an ionized carboxylic acid) Negatively charged sulfhydryl Uncharged amine group HN Imidazole 15. Identify the amino acids with the following side chains and also define if they will work as acid...

  • answer questions 15) An apoenzyme + cofactor(s) - a) Inhibitor b) active site c) substrate d)...

    answer questions 15) An apoenzyme + cofactor(s) - a) Inhibitor b) active site c) substrate d) holoenzyme 16) Aspartate-transcarbamylase is an enveloved in a pathway that may produces molecule called Cytidine triphosphate. Cytidine triphosphate can bind to anot t o this enzyme, rendering the active site nonfunctional. This is an example of a) ATP hydrolysis b) competitive inhibition c) feedback inhibition d) allosteric activation 17) Which of the following is false regarding fermentation? a) fermentation occurs in the absence of...

  • Place the following mechanisms to generate ATP in order starting with the one that produces the...

    Place the following mechanisms to generate ATP in order starting with the one that produces the few ATP's and ending with the one that produces the most ATP's per glucose molecule a anacrobic, fermentation, aerobic b) fermentation, aerobic, anaerobic c) acrobic, fermentation, anaerobic d) fermentation, anaerobic, acrobic e) anaerobic, aerobic, fermentation 2) Ry what type of phosphorylation are ATPs made by fermentation? a) substrate-level phosphorylation b) oxidative phosphorylation c) a combination of both types 3) This diagram represents a biochemical...

  • Can someone please check my answers and aid in #12? 1. The amide nitrogen of glutamine:...

    Can someone please check my answers and aid in #12? 1. The amide nitrogen of glutamine: A. represents a nontoxic transport form of ammonia. B. is a major source of ammonia for urinary excretion. C. is used in the synthesis of asparagine, purines, and pynimidines. D. can be recovered as ammonia by the action of glutaminase. E. all of the above are correct. 2- Which of the following statements about glutamate is NOT true: a It can be synthesized in...

  • Immunology Question May you check my answers for 2a and 2b and see if: the information...

    Immunology Question May you check my answers for 2a and 2b and see if: the information is being accurately presented, there is no unneeded information, and most importantly it is answering the question? I added more information to strengthen my answer so hopefully, it is better this time around. Thank you in advance! 2) Candida albicans is an opportunistic fungal pathogen in humans, and can cause a few irritating, but non- life threatening, infections in healthy individuals. However, in immunocompromised...

  • please answer all the questions Question 8 0 / 1 pts Our understanding of RNA    ...

    please answer all the questions Question 8 0 / 1 pts Our understanding of RNA     was non-existent until 2000    started with the identification of a tRNA which suggested a method of converting DNA to protein     began to identify that DNA-->protein--> RNA     stopped growing after it's original discovery in the 70s IncorrectQuestion 10 0 / 1 pts Enzymes allow for chemical reactions to occur in the cell that may not naturally occur at the right place at...

  • thats all the information that he gave us to solve the question. Thank you for trying...

    thats all the information that he gave us to solve the question. Thank you for trying anyways X C E Question 23 1 pts The free-energy changes for the transfer of individual amino acid residues from a hydrophobic to an aqueous environment are given as follows: Amino acid AG of transfer (kJ/mol Proline -0.8 -12.6 Histidine 6.7 Alanine Methionine 14.3 Based on this information, which of these amino acid pairs is MOST likely to be represented in membrane-spanning alpha helices?...

  • Based on the document below, 1. Describe the hypothesis Chaudhuri et al ids attempting to evaluate;...

    Based on the document below, 1. Describe the hypothesis Chaudhuri et al ids attempting to evaluate; in other words, what is the goal of this paper? Why is he writing it? 2. Does the data presented in the paper support the hypothesis stated in the introduction? Explain. 3.According to Chaudhuri, what is the potential role of thew alkaline phosphatase in the cleanup of industrial waste. CHAUDHURI et al: KINETIC BEHAVIOUR OF CALF INTESTINAL ALP WITH PNPP 8.5, 9, 9.5, 10,...

  • I need to write a conclusion for this lab. Based off these results what kinds of...

    I need to write a conclusion for this lab. Based off these results what kinds of conclusions can be drawn? S OY Orre tes. A, B. Color, pH, Specific Gravity, and Electrolytes "Normal Urine Specimen" Test A. Color I clear "Abnormal Urine Specimen" slightly cloudy PH 2 1.10 gime! Specific gravity 0.70 glume - B. Electrolytes (Indicate absent - present +, strongly present ++) nornal Nat CI SO,2- PO,- 219 C-F. Glucose, Ketone Bodies, Protein, and Urobilinogen "Normal Urine Specimen"...

ADVERTISEMENT
Free Homework Help App
Download From Google Play
Scan Your Homework
to Get Instant Free Answers
Need Online Homework Help?
Ask a Question
Get Answers For Free
Most questions answered within 3 hours.
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT