Question

Polarity and Solubility Predictions nirections: Show your molecule below. Circle or highlight all polar portions of the molecul water or olarity, involved. Fin your drug. of your drug and comment on any discrepancies. e. Make a reasonable prediction about whether your molecule will be soluble in not and explain your reasoning. If your molecule seems to be borderline in making it difficult to predict solubility, explain your reasoning and the difficulty d a source (Merck Index, PDR, etc.) that discusses the water-solubility of Compare your predictions with the information you find on the water-solubility Malcalc山pit or

Answer 1

therefore solubity is decreaseas,due to waterphobic nature of molecule.

Molecule Lipitor is a tablets. Atorvastatin is a HMG - inhibitor Lipitor tablets containing Atrorastatin is a practically in soluble in water at pH 4.0 I very slightly soluble in water at pH7.4 phosphate buffer. This is when in salt form calcium salt it is insoluble in water. Polarity: In hear Hydrophobic bonding might in interaction between electron cloud of phenyl and phenyl carbonic side chain and the charged a residue. The relative strength of this type of pi electron are cloud interaction 1. K columns/mol