Question

Name 3 examples of entropy forces (interactions) we learned in chapter 7 that are responsible for self-assembly of macro molecules. Give a brief explanation for each of them.(Hint lecture note # G, H, I) 1.

(Biophys Nelson)

Answer 1

Self-assembly is a process in which a set of components or constituents spontaneously forms an ordered aggregate through their global energy minimization. A vast number of macromolecules (like proteins, nucleic acid sequences, micelles, liposomes, and colloids) in nature adapt their final folding and confor­mation by self-assembly processes. There ex­ist many examples in the literature of natural self-assemblies which occur spontaneously due to the forces of nature.

Protein folding, diamondoids as host-guest chemis­try molecular receptors, DNA double helix, formation of lipid bilayers, formation of mi­celles, micelle coacervates and steric colloids are some examples in which self-assembly is the dominant phenomenon.

Responsible forces:

1. Molecular building blocks;

2. Intermolecu­lar interactions;

3. Reversibility (or adjust­ability);

4. Molecular mobility (due to mixing and diffusion);

5. Process medium (or envi­ronment).