A 41-year-old, 70 kg male patient with severe burns arrives in the ER and needs to...
A 41-year-old, 70 kg male patient with severe burns arrives in the ER and needs to be given IV morphine to treat his pain. The Vd for morphine is 230 L for a 70 kg patient. What IV loading dose do you need to rapidly achieve a therapeutic level of 60 ng /ml to relieve his pain?
a. 3.8 ng
b. 13.8 ng
c. 3.8 μg
d. 13. 8 μg
e. 13.8 mg
Homework Answers
Correct answer is : (e.) 13.8 mg
Explanation
volume of IV = 230 L = 230 x 103 mL
concentration of morphine = 60 ng/mL
mass of morphine = (concentration of morphine) * (volume of IV)
mass of morphine = (60 ng/mL) * (230 x 103 mL)
mass of morphine = 13.8 x 106 ng
mass of morphine = 13.8 x 106 ng * (1 mg / 106 ng)
mass of morphine = 13.8 mg
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