Label the function groups of the drug Enalaprilat the active metabolite of the drug Enalapril.
Label the function groups of the drug Enalaprilat the active metabolite of the drug Enalapril.
Give an example of a chemical that is converted to an active metabolite by sulfation
Enalapril is an anti-hypertension "prodrug" (1.6., a drug precursor) that is inactive until the ethyl ester (arrow in figure) is hydrolyzed by esterases present in blood plasma. The active drug is the dicarboxylic acid ("enalaprilat") that results from this hydrolysis reaction Enalaprilat is a competitive inhibitor of the angiotensin-converting enzyme (ACE), which Cleaves the blood-pressure regulating peptide angiotensin I. ACE has a K_M = 52 mu M for angiotensin I, which is present in plasma at a concentration d 75...
1) Fosamax has six acidic groups. The structure of the active form of the drug is shown in the figure below. (Notice that the phosphorus atom in Fosamax can be surrounded by more than eight electrons since P is below the second row of the periodic table.) A)The OH groups bonded to phosphorus are the strongest acids of the six groups. Why? a) Because phosphorus atom is less electronegative rather than atoms bonded to other acidic groups. b) Because the...
7. Explain the basics of enzyme function and structure (sketch an enzyme and label the active site, allosteric site, where the substrate binds, where competitive and non-competitive inhibitors bind). Include how many different reactions can be catalyzed by an enzyme and how many times an enzyme can catalyze that reaction.
Circle and label the functional groups in the molecules below: Circle and label the functional groups in the molecules below:
QUESTION A drug binds to the active site of an enzyme. If atis bound to the active site of the enzyme, it prevents substrate binding This drug 10
Identify the functional groups in the psychedelic drug below, nicknamed, LSD Identify the functional groups in the psychedelic drug below, nicknamed, LSD
Identify the functional groups Find H-bond donors and acceptors Identify any acidic or basic groups and draw the compound at various pHs using the pKa tables Calculate the solubility Identify potential molecular interactions that are possible when the drug binds to its target. If the pharmacophore for this drug includes the propanolamine and the aryl ring, propose an isosteric modification that will still produce an active drug. Simplify the drug, yet still produce an active drug Propose a modification that...
Subject label Blood pressure Reading before XAI XA2 XA3 ΧΑ4 XAS ΧΑ6XA7XA8 ΧΑ9 Drug A treatment Blood pressure Reading after YAIYA2YA3YA4YASYA6YA7YASYA9 Drug A Treatment Subject label Blood pressure Reading before XB1 XB2 XB3 XB4XB5 XB6 XB7 XB8 XB9 Drug B treatment Blood pressure Reading after YB1 YB2 YB3 YB4 YB5 YB6 YB7 YBS YB9 Drug BTreatment i)What test would you do to find out if Drug A is effective? a)when data follows normal distribution b)when data does not follow normal...
What is/are the main active drug in organo- platinum complexes?