Draw the chemical structure of the following tripeptide: Asn - His - Glu. Point out all locations in this peptide that carry a charge.
All the encircled positions can carry charge at different pH values.
This is the structure of the same tripeptide at highly acidic medium when all the groups are protonated.
At very basic pH all these groups will be deprotonated.
This depends upon the pKa value of each encircled group.
Draw the chemical structure of the following tripeptide: Asn - His - Glu. Point out all...
25 points Draw the structure of the following protein fragment. H2N-Ser-Pro-Glu-His-Asn-Tyr-COOH
What tripeptides could be produced from the partial hydrolysis of the following peptide: His-Glu-Ala-Asn-Asn?
Draw structure of this peptide at pH 7 and at pH 11. Ala-Arg-Asn-Asl-Glu-Ser-Gly Asp*
Draw the Lewis structure of the pentapeptide Met-Glu-Leu-His-Lys as it will exist at the following pH's РH 2.5 a. b. рH 7.0 pH 10.0 с. d. What is the isoelectric point for this peptide? Draw the Lewis structure of the pentapeptide Met-Glu-Leu-His-Lys as it will exist at the following pH's РH 2.5 a. b. рH 7.0 pH 10.0 с. d. What is the isoelectric point for this peptide?
Met-Ala-Arg-Tyr-Ala-Asn-Asn-Glu__Lys-Glu-Leu-Leu-Tyr__Arg-Tyr-Ala-Asn__Phe-Leu-Ala-Asn-Asn-Ile-Gly-Ala-Asn__Ile-Ser__Ile-Asn-Thr-Glu-Arg-Glu-Ser-Thr-Glu-Asp__Ile-Asn__ His-Glu-Arg__Phe-Ala-Thr-His-Glu-Arg-Ser__Thr-Arg-Ile-Gly-Leu-Tyr-Cys-Glu-Arg-Ile-Asp-Glu__Leu-Glu-Val-Glu-Leu-Ser__Ser-Ile-Asn-Cys-Glu__His-Glu-__His-Ala-Pro-Pro-Ile-Leu-Tyr__Glu-Ala-Thr-Ser__Val-Ala-Asn-Ile-Leu-Leu-Ala__Cys-Ala-Lys-Glu-__Ala-Asn-Asp__Pro-Glu-Cys-Ala-Asn__Pro-Ile-Glu__Trp-Ile-Thr-His__Phe-Arg-Ile-Glu-Asp__Cys-His-Glu-Glu-Ser-Glu-Cys-Ala-Lys-Glu__Ile-Cys-Glu__Cys-Arg-Glu-Ala-Met__Glu-Val-Glu-Arg-Tyr-Asp-Ala-Tyr__Ala-Asn-Asp__Ser-His-Glu__Ile-Ser__Asp-Glu-Val-Ala-Ser-Thr-Ala-Thr-Glu-Asp__Thr-His-Ala-Thr__Asp-Ile-Ser-Glu-Ala-Ser-Glu-Ser__Leu-Ile-Lys-Glu__His-Glu-Ala-Arg-Thr__Asp-Ile-Ser-Glu-Ala-Ser-Glu__Ser-Leu-Glu-Glu-Pro__Ala-Pro-Asn-Glu-Ala__Ser-Glu-Val-Glu-Arg-Glu__Trp-Glu-Ile-Gly-His-Thr__Gly-Ala-Ile-Asn__Trp-Ile-Leu-Leu__Ala-Arg-Ile-Ser-Glu__Ile-Phe__His-Glu__Lys-Glu-Glu-Pro-Ser__Thr-His-Ile-Ser__Glu-Ala-Thr-Ile-Asn-Gly__Pro-Ala-Thr-Thr-Glu-Arg-Asn__Tyr-Glu-Thr__Ile-Phe__His-Glu__Trp-Trp-Trp-Trp-Ile-Ile-Ile-Ile-Ile-Leu-Leu-Leu-Leu-Leu-Ser-Ser-Ser-Ser__Cys-His-Ala-Asn-Gly-Glu__Ile-Asn__His-Ile-Ser__Leu-Ile-Phe-Glu-Ser-Thr-Tyr-Leu-Glu__His-Glu__Cys-Ala-Asn__Ser-Thr-Ile-Leu-Leu__Arg-Glu-Met-Ala-Ile-Asn__His-Glu-Ala-Leu-Thr-His-Tyr__Ser-Ala-Ser-Ser-Tyr__Ala-Asn-Asp__Ala-Leu-Arg-IleGly-His-Thr 1.) Write out the 1 letter amino acid abbreviation for each of the three-letter amino acid abbreviated words listed in the given sequence. The __ indicates a space in between the words. Use www.expasy.org and other bioinformatic tools to generate the following bioinformatic data for the given polypeptide sequence. You must give the name and link to the program you used to generate the data: 2.) Compute the pI and Mw (isoelectric point and molecular mass, respectively) of...
What is the pI of the following peptide, Leu-Glu-His-Tyr? Show all your work, i.e. draw all the peptide structures (may be neatly hand drawn). ii) What is the overall charge at pH 3.5? Why? iii) What is the overall charge at pH 9? Why?
7a. Glutathione (GSH) is a cys-containing tripeptide with the sequence Y-glu-cys-gly. The y- glu-cys means that the first peptide bond is between the y-carboxylate group and not the a-carboxylate group that is more typical. Draw the structure of glutathione. 75. GSH helps cells cope with oxidative stress (e.g. peroxides) by becoming oxidized in place of other biomolecules: 2 GSH +R-O-O-H (a peroxide) -> GSSG + ROH (an alcohol) + H2O Draw the structure of oxidised glutathione.
6. A peptide has the sequence Cys-His-Phe-Glu-Ala-Arg a. Write the single letter sequence of the peptide b. Calculate the percentage and indicate the charge of the predominant peptide species at pH 6.5. Use the following pKa values: pKa Cys = 8.3, pKa N-terminus = 10.8, pKa His =6.0, pKa Glu = 4.3, pKa Arg = 12.5, pKa C-terminus =2.0 c. What is the charge of the peptide at pH 4.3? d. Draw the chemical structure of the predominant peptide species...
Draw the structure of the peptide Arg-Met-His-Val-Glu, label the coplanar atoms in one peptide bond and estimate a pI.
Draw the structure for Asp-Cys-Gly-Tyr. Draw the molecule on the canvas by choosing buttons from the Tools (for bonds an Templates toolbars, including charges where needed. (Express vour answer Enter the one-letter abbreviation for Asp-Cys-Gly-Tyr. Spell out the one-letter abbreviation for the peptide. Draw the structure for Asn-Tyr-Asp-Glu-Tyr. Draw the molecule on the canvas by choosing buttons from the 1 Templates toolbars, including charges where needed. (Express y Trna Aqu. t2D A Part D Enter the one-letter abbreviation for Asn-Tyr-Asp-Glu-Tyr....