Question

18. List two drugs that display zero-order kinetics.

19. Drugs showing zero-order kinetics of elimination: a. Are more common than those showing first-order kinetics. b. Decrease in concentration exponentially with time. c. Have a half-life independent of dose. d. Show a plot of drug concentration versus time that is linear. e. Show a constant fraction of the drug eliminated per unit of time.

20. Acyclovir is a compound that is used to treat herpes simplex virus. In vivo activation of acyclovir is required for anti-viral activity as shown here: Based on this in vivo activation process, what is acyclovir’s actual role in viral inhibition? A. prodrug B. active drug C. active metabolite D. inactive metabolite

21. List two inducers of CYP450.

22. List two inhibitors of CYP450.

Answer 1