Question

Assume you have identified a lead compound which has the desired activity, however tests show that it is not absorbed well when given orally. Which of the following represents a reasonable next step in the drug development process?

	A.	Try a structure based virtual screening approach.
	B.	Screening a library of unrelated molecules to find a better candidate
	C.	Modifying the compound to make it more hydrophobic
	D.	Modifying the compound to add charged functional groups.

Answer 1

The next step in the drug development will be modifying the compound to add charged functiinal groups, as they'll have better interaction with water, which will increase their chances of working and might improve efficiency.

Hence option d is correct