4. Describe the role played by glutamine in the transport of nitrogen.
4. Describe the role played by glutamine in the transport of nitrogen.
Homework Answers
Glutamine contains two nitrogen groups and serves as a major means of nitrogen transport between tissues. It is a primary substrate for ammonia synthesis in the kidney and is also required for synthesis of nucleotides and numerous other macromolecules.
Glutamine synthetase (GS) is an enzyme that plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine.
Glutamate + ATP + NH3 → Glutamine + ADP + phosphate
Glutamine synthetase uses
ammonia produced by nitrate reduction, amino acid degradation, and
photorespiration.The amide group of glutamate is a nitrogen source
for the synthesis of glutamine pathway metabolites.
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4. Describe the role played by glutamine in the transport of
nitrogen.
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