Question

4 Which of the fotlowing is the most reactive carhosylie acid derivative A) ester D) anhydride 2 nitrile D) acid chloride E) amide 11) Typically, amides will hydrolyse under A) stronger B) more dilute conditions than esters C) milder D) less vigorous E) more saline 12) 1-Methyleyclopentanol is classified as A) a primary aloohol B) a secondary alcohol C) a tertiary alcohol D)a phenol E) an enol 13. For a diene to undergo a Diels-Alder reaction it must: be substituted with electron-withdrawing groups be able to adopt an s-trans conformation be substituted with electron-donating groups be able to adopt an s-cis conformation a. b. c. d. 14. For Diels-Alder cycloaddition reactions to take place most rapidly and in highest yield the dienophile must: be substituted with electron-withdrawing groups be able to adopt an s-trans conformation be substituted with electron-donating groups be able to adopt an s-cis conformation a. b. c. d. Page 4 Dr. Hany F. Sobhi Chem 308 S 2019

Answer 1

10. D) acid chloride

More electronically polarized groups are more reactive. Hence, acid chlorides are more reactive than anhydrides, esters, amides and nitriles.

11. A) stronger

Amides are less reactive than esters. Hence, they require stronger conditions.

12. C) a tertiary alcohol

The carbon that the -OH group is attached to, is inturn attached to 3 other carbon atoms.