Choose a pharmaceutical molecule. Draw its structure and assess its bioavailability using Lipinski’s rules

Question

Question

Answer 1

Answer #1

Omeprazole is the pharmaceutical molecule.

It's structure :

O Omeprazole is a popular drug that conforms to Lipinskis rule of five. z. O= IZ O

Lipinski's rule states that, in general, an orally active drug has no more than one violation of the following criteria :-

No more than 5 hydrogen bond donors (the total number of nitrogen–hydrogen and oxygen–hydrogen bonds)

No more than 10 hydrogen bond acceptors (all nitrogen or oxygen atoms)

A molecular mass less than 500 daltons

An octanol-water partition coefficient[6] (log P) that does not exceed 5

Answer 2

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