Question

Mr. Javier presents to your SICU after a multiple vehicular accident and sustained massive head injuries. He requires deep sedation in order to reduce his cerebral metabolic rate and thus reduces cerebral oxygen demand. which mode of ventilation order would you challenge?

Answer 1

Ans) Patients who are critically ill experience numerous physiological derangements and commonly require long duration of analgesic and sedative therapy.

- The ideal sedative or analgesic agent should have a rapid onset of activity, rapid recovery after drug discontinuation, predictable dose response, lack of drug accumulation and toxicity.

- Sedative regimens in the neuro ICU are complex owing to the need to monitor these patient’s serial neurological examinations. So, to optimize care clinician should be familiar with the pharmacokinetic and pharmacodynamic variables that can affect the safety and efficacy of analgesics and sedatives.