5. 10points. Determine which of substitution or elimination mechanism works best in order to form the major product...
5. 10points. Determine which of substitution or elimination mechanism works best in order to form the major product of the following reaction? (hint: draw chair conformation for the molecule) CH3 NaOCHCH, CH,CH,OH "CH3 Hac CH3
PARTH 420points. Explain the following resulting posible mechanisms CH 5. 10points. Determine which is limination mechanism works best in order to form the major prodext of the following action (hint: draw chair cofomation for the molecule) HyCCM
Your Turn Which Mechanism is it? 5. In each of the problems below, consider the E1 or E2 reaction occurs then show the mechanism and product or products. Label major and minor products where applicable. a. Reaction of 1,1-bromomethylcyclohexane and sodium ethoxide in ethanol CH, OH сн. b. Reaction of (1R 2R) 1-bromo-2-methylcyclohexane and sodium ethoxide in ethanol. HINT: You should draw the ring in a chair conformation first. CHE 90 -CH, CH,CH,OH C. Reaction of (15,2R) 1-bromo-2-methylcyclohexane and sodium...
Challenge CH 235R F 2019 Week 11 Problem #2 1. Predicting Major and Minor elimination products For each of the following alkenes, draw all possible elimination products for the following molecules, ignoring the mechanism. Indicate the major alkene product. noted II. E2 Eliminations on substituted cyclohexane halides Consider the two isomeric compounds below. a) Draw each in a chair conformation, b) Show the mechanism and final alkene product(s) that form from an E2 reaction with CH,O/CH,OH. c) If more than...
For each of the following reactions, determine which ELIMINATION mechanism (E1 or E2) will occur. Alkyl Halide Substitution: Methyl 1° 2° 3° Base Strength: Strong Weak Mechanism Type: E1 E2 Draw the mechanism that leads to ALL products for the reaction. Finally, underline the major product of the elimination reaction: H3C OH H2C H2C1 Br CHE
8. Identify the major substitution product in the following reaction: Br 7 сH, CH;он. HC H 9. Which halide ion would react the fastest with cyclopentyl p-toluenesulfonate (below) in ethanol/water? What would the final product of that reaction be? OTS 10. Draw a detailed mechanism for the following reaction. Hint: The first step is deprotonation of the hydroxyl group. NaOCH; ~ OH NOCH CH;ОН
25. Which two reactions will never go through an E1 or Se 1 mechanism? Why not? NaOCH V ICH,CH, OH CH,OH X Hyo 26. Substitution and elimination reactions always compete with each other. For each reaction below draw the probable substitution and elimination products, considering if a 1" or 2" order mechanism is likely. Then identify the major product 27. Draw the major organic product, then the curved arrow mechanism for each reaction, considering whether the major pathway should be...
the following compound is 9 Which is the major product of the follow CHOCH, OH NaBr ? of the following substitution reaction? D) All of the Above E) None of the Above A) CH₃ CH₂ Br B) CH3CH(Na, c) CH₂-E-H 20 Which is the major product of 5 CHA CH=CH-CH2 HBr ? the following substitution reaction? major product of CHE OH SHA A) CH₂ CH-CH=CH3 CH2 () CH3 C=CH-CH2 B) CH3 C- CH₂ - CH3 D) None of the Above...
For each of the following reactions, determine which ELIMINATION mechanism (E1 or 2) will occur. Alkyl Halide Substitution: Base Strength: Mechanism Type: 2° 3° Methyl Strong E1 1° Weak E2 Draw the mechanism that leads to ALL products for the reaction. Finally, underline the major product of the elimination reaction: NaOCH Challenge Problems: Synthesis: Predicted Ability: Good Average Poor Actual Ability: Good Average Poor Propose a synthesis from the starting material to obtain the indicated goal molecule. Note that any...
Some mechanism questions – another look at substitution and elimination mechanisms. 2. Some mechanism questions - another look at substitution and elimination mechanisms. Cyclohexanol is treated with hydrochloric acid. A mixture of three products form OH HCI Cl i. Which product(s) is (are) the result of s ubstitution? ii. Of the products A and B which should have a higher yield? iii. The mechanism for all three products has the same step: the formation of a carbocation. Draw the carbocation...