ANSWER - Question 14a:
Reagents A:
Reagents B:
Structure C:
The epoxyde in compound 5 is opened, and the reactant atacks the carbon with the phenyl substituent because this is the most electrophilic carbon
Structure D:
The catalytic hydrogenation of structure C reduces the NO2 group to an NH2 group
Structure E:
The group OH of compound 6 is transformed into an OAc group with the acetic anhydride
Reagent F:
The NaH deprotonates the structure E, then, it attacks the reagent F to produces the compound 7
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ANSWER - Question 14c:
The proposed mechanism is:
14. The following sequence of reactions outlines a synthesis for the calcium-channel blocker Diltiazem, which is used...