1) a)
You are working at a pharmaceutical company and the CEO wants to develop a new Alzheimer’s disease drug. Write a brief essay describing what you know about the current development of β-secretase inhibitors and immunotherapy drugs.
For each drug included in your answer, give the hypothesis that has been tested, any animal studies performed and the outcomes of human trials.
Finish your essay by describing to the CEO your own hypothesis on how the company could invest its millions for EITHER early diagnosis OR treatment of Alzheimer’s disease. (20 marks)
1) b)
(i) Draw and label a graph that represents Alzheimer’s disease biomarker development throughout the course of a person’s lifetime. (7 marks)
(ii) Indicate on your graph where treatment currently starts, and where treatment needs to start in order to be effective. (1 mark)
(iii) Describe TWO brain scanning techniques that can be used to determine the pathology of Alzheimer’s disease. (4 marks)
(iv) Explain THREE ways that Aβ42 oligomers can exert toxicity. (6 marks)
(v) Describe your own hypothesis on how we could EITHER diagnose Alzheimer’s disease before memory loss has become apparent OR treat it once it has. (2 marks)
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1) a) You are working at a pharmaceutical company and the CEO wants to develop a new Alzheimer’s disease drug. Write a b...
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