Question

For 10/23 please read chapter 8. Try problems at the end of chapter 8. 1. Complete the following reactions indicate all products and the mechanisms of the reactions). La H2O/EtOH/60°C H2O/EVOH/60°C La EtOK/EtOH b. NaOH DMF NaSCH; DMF TSCI DBU A Py

Answer 1

H₂O leton 6 with SNI Reaction occur at at Alkyl chlona Alkyl chloride P ho iске сес, Х.с. Mechanismo In polar, © Liege Shift prome Solvent Jerón Product ☺ with with Elokleton Etok/aton Ez el Go elimination occur at alkyl chloride Hº Che, dien. EPOK, cron – Mechanism elimination Heu must be antperiplaner for ez to each other - Gton -kce Naon, DMF © with SN2 reaction occur at alky, bromide Ngon On Drag

Mechanismes SN2 reaction occur via s coordinaled transition State and inversion in Stereochemistry observed. DMY SN2 5-coordinated transition state 0n I product 2) with Na SCN3 ;AMP She reaction occur at alkylbromide Mascha Sch3 Omp Mechanisma son s-coordinated transition l-Bro State State

© * with Tsce Pyridine -on gets convertee a, Pyridine ,-on gets converted into -OTS Bu is bulky and strong base so gives elimination reachion. Ooh 754, Dots dou, a Mechahah• Се» аса са се PY to O Bu givex Site. Ez elimination selectivily remove it from less substituled 015 DBY DBU 4,8 - Diaza bicydo (S.4.0) undee-fene & non nucleophilic bulky base.