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If a protecting group was not used, what would be the product of the Grignard reaction?

CHOEt + HO OH P-TOH toluene reflux QO CH -CH CH2 O Et 0 2 O 2 PhMgBr ether 0 0 Ph. Ph. CHIPh HCI, HO acetone reflux CH3 HO CH
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Answer #1

As we know that Grignard reagent undergo nuclrNucleop addition reactions.

Between ketone and ester, ketone is more reactive towards nucleophile (Grignard reagent) than ester

Hence Grignard reagent reacts with ketone and gives tertiary alcohol which then undergoes cyclisation with ester.

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