Question

SM Bonus: (10 pts) Starting from Benvene and using reagents that we have discussed in class, design a synthesis molecule (TM).

Answer 1

For the first transformation, we need to perform hydration of alkyne to produce the corresponding ketone. Our target molecule is z--type alkene. so here we have to remember wittig reaction.  

In the second problem, we start from benzene to benzaldehyde proceeded by nitration. After nitration, we converted into 3-hydroxy benzaldehyde. Then treated with nitromethane in the presence of a base. At last nitro group reduction performed to achieve our target molecule.

H₂SO4 = H. s . + H2O Hy sou o pphen I Withig reaction THE, 78°C

CHO со, на NaN Ha | Sncez NANO, aq. H2SO4 CHO ECHO ET - H2SO4 : NHSO4 NIHS HISOA A 140 OH CHO CH₂ NO L No polc Н, NaOne OH NH (product)