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Pacific Blue ОН НО

Dye preparation mechanics

How can I get this dye

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Answer #1

3,5-difluoro-2,4-dihydroxybenzaldehyde on reaction with malonic acid in the presence of methane sulphonic acid forms a 6,8-difluoro-7-hydroxy-2-oxochromane-3-carbaldehyde which on further oxidation with CrO3 in presence of water yields Pacific blue.

HO1 CHO 3,5-difluoro-2,4-dihydroxybenzaldehyde malonic acid CH3SO3H CHO H20 Cros Pacific Blue 3-(2,4-difluoro-3-hydroxyphenox

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