skip 5b 4. Show how you would synthesize the following aldehydes by adding the appropriate Grignard reagent to f...
Show how you would synthesize the following acid using carbonation of a Grignard reagent. Show how you would synthesize the following acid using carbonation of a Grignard reagent.
Show how you could synthesize the products below using a Grignard reagent and appropriate electrophile by drawing the overall balanced equation. No mechanisms are required for this question. You do not need to show formation of the Grignard reagent. [2 marks] HO H3COH Ph Phi
3. Show how you would add a Grignard reagent to an acid chloride to synthesize 4-phenylheptan-4-01 4. Show how you would accomplish the following synthesis in good yield. OH benzoic acid N.N-dimethylbenzamide NH HO hexanol heptane-1-amine 0 0 methyl 2-phenylacetate 3-phenylpropionitrile но-л-он
Predict the products of the following reactions.
a.
b.
c.
(1) excess CH Mg! CI (2) H30* (1) DIBAL-H (-78 °C) (2) H30 OCH (1) DIBAL-H (-78 °C) (2) H2O
Predict the products of the following reactions.
a.
b.
c.
(1) excess CH Mg! CI (2) H30* (1) DIBAL-H (-78 °C) (2) H30 OCH (1) DIBAL-H (-78 °C) (2) H2O
Problem 1. Synthesize the following alkene through the Wittig reaction of a carbonyl compound and a Wittig reagent. 2,3-diphenyl-2-butene 2. Predict the products of the following reactions. Casco CHCH.CHCH, CHCH.CH но ats ОО 2.0 CH,CHACHCH,CHCHOCH.CH, CH 3. A useful and general method for the synthesis of alcohols is the addition of Grignard reagents to carbonyl compounds. Show what Grignard reagent and what carbonyl compound you would start with to prepare the alcohol below. List all possibilities. 2-methyl--butanol 2-METHYL-2- BOTANIC
Use retrosynthetic analysis to suggest two paths to synthesize 2-methyl-3-pentanol using the Grignard reaction. (Click and drag the appropriate image to the correct position in the following reactions.) Aldehyde Grignard route 1 MgBr OH H,O or Aldehyde Grignard 2-methyl-3-pentanol route 2 CH3CH2CH MgBr 0 CH,CHMgBr CHy CH CH,Mg8
1. Provide the reagents necessary to make the following Grignard Reagent. Include the structures of any intermediates that may be formed to arrive at the final product. Br: Mg Br 2. Predict the product for the following reactions. Br Mg/ether 1. CO2 2. H 0+ :Br: Mg/ether 2. H,O:
2. Predict the products of the following Grignard reactions. 1. excess EtMgBr 2. H2O Och3 B. o 1. excess CH3MgCI 2. H30*
Show how you would use Grignard syntheses to prepare the
following alcohols from the indicated starting materials and any
other necessary reagents. Draw the Grignard reagent and any other
organic reagents needed.
11 RUVIUWI Constans i Pendulu Part F Show how you would use Grignard syntheses to prepare the following alcohols from the indicated starting materials and any other necessary reagents. Draw the Grignard reagent and any other organic reagents needed. ОН -C-CH CH, from C-OCH.CH Draw the molecules on...