Question

1. M. L. Bender and T. H. Marshall [J. Am. Chem. Soc., 90, 201(1968)] studied the elastase-mediated hydrolysis of p-nitrophenyl trimethylacetate to produce p-nitrophenol. These authors have proposed the following mechanism for this reaction: k. k2 E A ES where S, the substrate, is p-nitrophenyl trimethylacetate; P, the product, is p-nitrophenol; and A is trimethylacetiç acid. k,= 150 m3mole-ksec and k2= 2.60 ksec1. (a) Derive an equation for the rate of production of species P in terms of ki, k2, Eo (the total elastase concentration in its two forms, E and ES), and S the instantaneous concentration of substrate. (b) Lucky Bucky Chemical Company is investigating the production of p-nitrophenol by this process in a continuous-flow stirred-tank reactor with a volume of 0.3 m3. If 90% of the substrate is to be converted to the product, how large a volumetric flow rate can be processed in this reactor when the initial enzyme and substrate concentrations are 1 and 100 mol/m3, respectively?

Can you do b part in detail?