Question

Drug Miracurol (molecular weight 540 daltons) binds to a key oncogenic proteins, Malevolin, with a dissociation constant of 0.1nM.

A.what is the standard free energy change of the binding reaction between Miracurol and Malevolin at a temperature of 37C. (R=8.314Jmol-1K-1)

B. what mass of Miracurol should be administered to a patient with a blood volume of 5.5L such that the final concentration of Miracurol in the patient's blood is enough to bind and inhibit at least 90% of Malevolin molecules?

C. Let's say, Miracurol also binds non-specifically to a normal cellular protein called Benevolin, with an affinity of 1μM. To minimize the side effect of Miracurol on the cellular functions carried out by Benevolin, a pharmacist decides to administer Miracurol to a patient such that the final concentration of the drug in the patent's body would be 10nM. At this concentration of Miracurol, what percentage of Malevolin is bound by the drug and what percentage of Benevolin is bound by the drug?

Answer 1

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The idacuda aso binds non- Specifically to s nodMal Ce|lulod Protein Called Benevolin H3 CH& H R R