What is the solubility of phenobarbital in a hydro-alcoholic solution containing 10% alcohol. The solubility of phenobar...
What is the solubility of phenobarbital in a hydro-alcoholic solution containing 10% alcohol. The solubility of phenobarbital in water and alcohol are approximately 1g per L and 1g per 10 mL, respectively.
Homework Answers
Solubility of phenobarbital in
Water -1gm/L =1000mg/1000ml=1mg/ml(w/v)
and in alcohal -1gm/10ml=1000mg/10ml=100mg/ml
Required solubility is 10% hydro-alcohalic solution=
10% alcohal +90% water(10ml+90ml)=1000mg+90mg=1090mg/100ml
Or 109mg/10 ml or 10.9mg/ml
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