Question

9. Multiple Myeloma • cell type affected • clinical manifestations • M Spike • Bence Jones proteins • pathogenesis of proteinuria and acute renal failure 10. What are the glycoproteins that are used for treatment of bone marrow failure and malignancy? 11. What are the precursors in the development of a neutrophil? 12. Where does the B cell develop and T cell develop prior to being moved to the peripheral lymphoid tissue? 13. What would indicate the need of neutropenic precautions and what is an average ANC?

Answer 1

Answer: Multiple myeloma:

1. Cell type affected: In the multiple myeloma, the white blood cells are affected as it becomes cancerous.
2. Clinical manifestation: The symptoms occurs are:

• Bone pain
• Vomiting
• Weakness
• Fatigue.

The risk factors involves such as race, gender as male are more prone to this disease, age as older people are more likely to get the disease.

3. M spike: The abnormal cells that are produced causes the M spike or the monoclonal proliferation of plasma cells.

4.Bence Jones proteins: These are the specific kind of diagnostic of multiple myeloma which causes in the organ impairment such as renal failure.