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What is one disadvantage of a meta-analysis? Meta-analyses attempt to combine studies of different types which may have been done at different times and may define the population of interest and/or the variables in slightly different ways. Meta-analysis may only be performed on cross-sectional data, and so cannot fulfill the conditions for determining causality, such as whether the supposed cause preceded the supposed effect in time. Meta-analysis cannot contain both experimental studies and observational studies, and so give incomplete information about the population of interest and the variables studied. Meta-analysis is an observational study of other studies and so it cannot determine causality, even though it takes much time and hence much money to complete
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