Question

8. Provide an efficient multi-step synthesis of 2 starting with 1. In your forward synthesis, indicate the reagents used for

5. Draw the major product for each of the following reactions or reaction sequences. Show stereochemistry where appropriate.

1) Fe, HCI H»NO,/H,SO 2) NaOH 1) HNO3 /H2SO4 2) NaNO, H2SO4 1) H.NO, /H2SO4 2) Fe, HCI 1) NaNO2 H2SO4 2) HBF

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Answer #1

NO2 Nach I aromatic Nucleo philic with respect to -NO2 CN substitution takes place at lave group. (of is Replaced wik & Ion)BEN CP LA(Hy to listen Que Chocolate con CH₂-UHq དང༌ ། བ ར ་ Ht (-H20) CHE_N=CH Itine \ CHQ-NH-Chien Target compound)payu tonjoureny clean Quest -C-CH3 ig Meta Directing - Nog to - NHe is Reduction group. Reaction 3 the N ENCO Nuq -Utdog Hy sOH3 OCH OCH Ť w No corre (Hel Hesoy na walang taon ang NHE Nante 10 CH3 с(43 Cuz HBFY Cho . OM is stronger Donating group Tha

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