Question

In each reaction box, place the best reagent and conditions from the list below. bupropion (Zyban TM (used to help people quit smoking) Br2, H20 CH3CH2CH2NH2 CH3COCI, AICB Cl2, FeCl3 m2, hv C12, H20 Cl2, hv Brz, NaOH CH3CH2COCI, AICI3 Cl2, NaOH CH3CH2CH2COCI, AICI Br2, H30. (CH3 3CNH2

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Answer #1

1) CH3CH2COCl, AlCl3

2) Cl2, FeCl3

3) Br2, H2O

4) (CH3)3CNH2

Explanation: Reaction of benzene with acid chloride and AlCl3 gives Friedel-Craft's acyaltion and produces acylated benzene as product. -COCH2CH3 group is an electron withdrawing group which directs the incoming electrophile to meta position. Reaction of carbonyl compound with Br2, h2O gives halogenation at alpha position. substitution of bromide ion with primary amine produces the required product.

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